Publications


  1. Fleurier S, Dapa T, Tenaillon O, Condon C, Matic I. (2022) rRNA operon multiplicity as a bacterial genome stability insurance policy. Nucleic Acids Res. 9;50(22):12601-12620. doi: 10.1093/nar/gkac332.
  2. Durand, S., Callan-Siddat, A., McKeown, J., Li, S., Kostova, G., Fernaud, J.R.H., Alam, M.T., Andrew Millard, Constaninidou, C., Condon, C., and E.L. Denham (2021). Identification of an RNA sponge that controls the RoxS riboregulator of central metabolism in Bacillus subtilis. Nucleic Acids Res. doi: 10.1093/nar/gkab444
  3. Durand, S. and Guillier, M. (2021) "Transcriptional and post-transcriptional control of the nitrate respiration in bacteria." Frontiers in Molecular Biosciences, https://doi.org/10.3389/fmolb.2021.667758
  4. Oerum, S., Dendooven, T., Catala, M., Gilet, L., Dégut, C., Trinquier, A., Bourguet, M., Barraud, P., Cianferani, S., Ben F. Luisi, B. F.., Condon, C.* and C. Tisné*. (2020). Structures of B. subtilis maturation RNases captured on 50S ribosome with pre-rRNAs. Mol Cell. https://doi.org/10.1016/j.molcel.2020.09.008
  5. Pellegrini, O., Gilet, L., Trinquier, A., Tolcan, A., Allouche, D., Durand, S., Braun, F. and C. Condon (2020). Assay of Bacillus subtilis ribonuclease activity in vitro. In: Methods in Molecular Biology: RNA remodeling proteins, Methods and Protocols. Ed: Marc Boudvillain. Springer 2nd Edition.MiMB. 2209:403-424, DOI: 10.1007/978-1-0716-0935-4_25.
  6. Gilet, L., Pellegrini, O., Trinquier, A., Tolcan, A., Allouche, D., Braun, F., Durand, S. and C. Condon (2020). Assay of Bacillus subtilis ribonuclease activity in vivo. In: Methods in Molecular Biology: RNA remodeling proteins, Methods and Protocols. Ed: Marc Boudvillain. Springer 2nd Edition. MiMB. 2209:387-401, DOI: 10.1007/978-1-0716-0935-4_24.
  7. Cai, Y., Usher, B., Gutierrez, C., Tolcan, A., Mansour, M., Fineran, P., Condon, C., Neyrolles, O., Genevaux, P. and T. R. Blower (2020). A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems.Science Adv 6:eabb6651 DOI: 10.1126/sciadv.abb6651.
  8. Šiková, M., Wiedermannová, J., Převorovský, M., Barvík, I., Sudzinová, P., Kofroňová, O., Benada, O., Šanderová, H., Condon, C., and L. Krásný (2020). The Torpedo Effect in Bacillus subtilis: RNase J1 Resolves Stalled Transcription Complexes. EMBO J. 39:e102500. https://doi.org/10.15252/embj.2019102500
  9. Durand, S., Callan-Siddat, A., McKeown, J., Li, S., Kostova, G., Fernaud, J.R.H., Alam, M.T., Andrew Millard, Constaninidou, C., Condon, C., and E.L. Denham (2019). Novel regulation from novel interactions: Identification of an RNA sponge that controls the levels, processing and efficacy of the RoxS riboregulator of central metabolism in Bacillus subtilis. BioRxiv doi: https://doi.org/10.1101/814905
  10. Braun, F and C. Condon (2019). RNA processing. In Encyclopedia of Microbiology, Ed. Thomas Schmidt. Elsevier 4th Edition. pp164-177 doi: 10.1016/B978-0-12-801238-3.02455-7.
  11. Ignatov D., Vaitkevicius K, Durand S, Cahoon L, Krajewski S, Liu X, Kallipolitis B, Rydén P, Freitag N, Condon C and Johansson J (2020) "An mRNA-mRNA interaction couples expression of a virulence factor with its chaperone in Listeria monocytogenes" Cell report. (30) 12, 4027-4040.e7. https://doi.org/10.1016/j.celrep.2020.03.006
  12. Trinquier A, Durand S, Braun F, Condon C. (2020) Regulation of RNA processing and degradation in bacteria. Biochim Biophys Acta Gene Regul Mech. doi: 10.1016/j.bbagrm.2020.194505.
  13. Trinquier A, Ulmer JE, Gilet L, Figaro S, Hammann P, Kuhn L, Braun F, Condon C. (2019) tRNA Maturation Defects Lead to Inhibition of rRNA Processing via Synthesis of pppGpp. Mol Cell. doi: 10.1016/j.molcel.2019.03.030.
  14. Baumgardt, K., Gilet, L., Figaro, S.,Condon, C. (2018) The essential nature of RNase M6 (YqfG) required for 3' maturation of B. subtilis 16S ribosomal RNA is suppressed by deletion of RNase R (2018). Nucleic Acids Res. doi: 10.1093/nar/gky488
  15. Condon, C., Piton, J. and F. Braun. (2018) Distribution of the ribosome associated endonuclease Rae1 and the potential role of conserved amino acids in codon recognition. RNA biology. 7, 1-6 doi: 10.1080/15476286.2018.1454250
  16. Durand, S. and C. Condon (2018) RNases and helicases in Gram-positive bacteria. Microbiol. Spectrum 6:RWR-0003-2017 doi:10.1128/microbiolspec.RWR-003-2017
  17. Ma, M., Li de la Sierra-Gallay, I., Lazar, N., Pellegrini, O., Lepault, J. Condon, C., Dominique, D. and H. van Tilbeurgh. (2017) Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase. Biochemistry. 474, 3599–3613.
  18. Braun, F., Durand S. and C. Condon (2017) Initiating ribosomes and a 5'/3'-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation Nucleic Acids Res. 45, 11386-11400.
  19. Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Lonjon, P., Guyon, C., Turan-Zitouni, G., Dzieciolowski, J., Becker,  K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J-M., Dideberg, O., Galleni,  M., Docquier, J-D. and J-F. Hernandez (2017) 1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-b-lactamases. ChemMedChem. 12, 972 – 985.
  20. Durand, S., Braun, F., Helfer, A-C., Romby, P. and C. Condon. (2017) sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation. eLife http://dx.doi.org/10.7554/eLife.23602
  21. Ma, M., Li de la Sierra-Gallay, I., Lazar, N., Pellegrini, O., Durand, D., Marchfelder, A., Condon, C., and H. van Tilbeurgh. (2017) The crystal structure Trz1, the long form tRNase Z from yeast. Nucleic Acids Res.  https://doi.org/10.1093/nar/gkx216
  22. Leroy*, M., Piton*, J., Gilet, L., Pellegrini, O.,L., Proux, C., Coppée, J-Y., Figaro, S. and C. Condon. Rae1 (YacP), a new endoribonuclease involved in ribosome-dependent mRNA decay in B. subtilis. EMBO. J. (36) 1167-1181. *co-first author
  23. Gourse, RL. and Condon, C. (2016) Classic spotlight: Visualisation of bacterial genes in action.  J. Bacteriol (198) 1554. doi: 10.1128/JB.00231-16
  24. DiChiara, J.M., Liu, B., Figaro, S., Condon, C. and D.H. Bechhofer.(2016) Mapping of internal monophosphate 5’ ends of Bacillus subtilis messenger RNAs and ribosomal RNAs in wild-type and ribonuclease-mutant strains. Nucleic Acids Res. (44) 3373-3389. doi: 10.1093/nar/gkw073.
  25. Condon, C. (2015) Airpnp: Auto- and Integrated Regulation of Polynucleotide Phosphorylase. J. Bacteriol 197:3748-3750
  26. Durand, S., Tomasini, A., Braun, F., Condon, C.* and P. Romby*. (2015) sRNA and mRNA turnover in Gram-positive bacteria. FEMS Micro Reviews.39:316-330 *Co-corresponding authors.
  27. Hotto A.M, Castandet, B., Gilet, L., Higdon, A. Condon, C. and D.B. Stern. (2015) Arabidopsis chloroplast Mini-Ribonuclease III participates in rRNA maturation and intron recycling. Plant Cell (27) 724-740.
  28. Durand, S., Braun, F., Lioliou, E., Romilly, C., Helfer, A-C., Kuhn, L., Quittot, N., Nicolas, P., Romby, P.* and C. Condon*. (2015) A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis. PLoS Genetics.*Co-corresponding authors. DOI:10.1371/journal.pgen.1004957
  29. Gilet, L., DiChiara, J.M., Figaro, S., Bechhofer, D.H. and C. Condon. (2014) Small stable RNA maturation and turnover in Bacillus subtilis. Mol. Microbiol. (95) 270-282
  30. Condon, C. (2014) RNA processing. In Reference Module in Biomedical Sciences, Michael Caplan (editor), Elsevier, Oxford. doi:10.1016/B978-0-12-801238-3.02455-7.
  31. Piton, J., Larue, V., Thillier, Y., Dorléans, A., Pellegrini, O., Li de la Sierra-Gallay, I., Vasseur, J.J., Debart, F., Tisné, C. and Condon, C. (2013) The B. subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates. PNAS (110) 8858-8863.
  32. Figaro, S.*, Durand, S.*, Gilet, L., Cayet, N., Sachse, M. and Condon C. (2013) Knockouts of the genes encoding ribonucleases RNase Y and J1 are viable in B. subtilis, with major defects in cell morphology, sporulation and competence. J. Bact. 195, 2340-2348. * Co-first authors.
  33. Durand, S., Gilet, L. and Condon, C. (2012) The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS Genet, 8(12): e1003181. doi: 10.1371/journal.pgen.1003181.
  34. Durand, S., Jahn, N., Condon, C*. and Brantl, S*. (2012) Type I toxin-antitoxin systems in B. subtilis. RNA Biology. 9, 1491-1497  * Co-corresponding authors.
  35. Pellegrini, O., Li de la Sierra-Gallay, I., Piton, J., Gilet, L. and Condon, C. (2012) Activation of tRNA maturation by downstream uracil residues in B. subtilis. Structure, 10, 1769-1777.
  36. Sinturel, F., Bréchemier-Baey, D., Kiledjian, M., Condon, C. and Bénard, L. (2012) Activation of 5'-3' exoribonuclease Xrn1 by co-factor Dcs1 is essential for mitochondrial function in yeast. PNAS 109, 8264-8269.
  37. Durand, S., Gilet, L., Bessières, P., Nicolas, P. and Condon, C. (2012) Three essential ribonucleases RNase Y, J1 and III control the abundance of more than half of B. subtilis mRNAs. PLoS Genet 8(3): e1002520. doi:10.1371/journal.pgen.1002520
  38. Dorléans, A, Li de la Sierra-Gallay, I, Piton, J, Zig, L., Gilet, L., Putzer, H. and Condon, C. (2011) Structure. Molecular basis for the recognition and cleavage of RNA by the bifunctional 5'-3' exo/endoribonuclease RNase J. Structure. 19, 1252-1261.
  39. Richards, J, Liu, Q, Pellegrini, O, Celesnik, H, Yao, S, Bechhofer, DH, Condon, C, and Belasco, JG. (2011) An RNA pyrophosphohydrolase triggers 5’-exonucleolytic degradation of mRNA in Bacillus subtilis. Mol. Cell. 43:940-949.
  40. Condon, C. and Gilet, L. (2011) The metallo-beta-lactamase family of ribonucleases. Nucl. Acids and Mol. Biol. 26:245-267.
  41. Condon, C. and Bechhofer, D. (2011) Regulated RNA stability in Gram positives. Curr. Opin. Microbiol. 14:148-54.
  42. Condon, C. (2010) What is role of RNase J in mRNA turnover? RNA Biol. 7:316-321.
  43. Mathy, N., Hebert, A., Mervelet, P., Dorléans, A., Bénard, L.,  Li de la Sierra-Gallay, I., Noirot, P., Putzer, H. and Condon, C. (2010) Ribonucleases J1 and J2 form a complex with altered enzyme behavior.  Mol. Microbiol (75) 489-498.
  44. Redko, Y. and Condon, C. (2010) Maturation of 23S rRNA in B. subtilis by RNase J1 and the 3’-5’-exoribonucleases RNase PH and YhaM in the absence of Mini-III. J. Bacteriol. (192) 356-359.
  45. Sinturel, F., Pellegrini, O., Tong, L., Condon, C. and Bénard, L. (2009) Real time fluourescence detection of exoribonucleases. RNA  (11) 2057-2062
  46. Fang, M., Zeisberg, W-M., Condon, C., Ogryzko, V., Danchin, A. and Mechold, U. (2009) Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis. (2009) Nucleic Acids Res. (37) 5114-5125
  47. Daou-Chabo, R and Condon, C. (2009) RNase J1 endonuclease activity as a probe of RNA secondary structure. RNA (15) 1417-1425
  48. Condon, C. RNA processing. (2009) In Encyclopedia of Microbiology, 3rd Edition, Moselio Schaechter (editor), Elsevier, Oxford. Vol. 5 pp. 395-408.
  49. Daou-Chabo, R., Mathy, N., Bénard, L. and Condon, C. (2009) Ribosomes initiating translation of the hbs mRNA protect it from 5’-to-3’ exoribonucleolytic degradation by RNase J1. Mol. Microbiol. (71) 1538-1550.
  50. Redko, Y. and Condon, C. (2009) Ribosomal protein L3 bound to 23S rRNA stimulates its maturation by Mini-III ribonuclease. Mol. Microbiol. (71) 1145-1154
  51. Condon, C., Pellegrini, O., Mathy, N., Bénard, L., Redko, Y., Oussenko, I., Deikus, G. and Bechhofer D.H. (2008). Assay of Bacillus subtilis ribonucleases in vitro. Methods in Enzymology. (447) 277-307.
  52. Bechhofer, D.H., Oussenko, I., Yao, S., Mathy, N. and Condon, C. (2008) Analysis of mRNA decay in Bacillus subtilis. Methods in Enzymology. (447) 259-276.
  53. Pellegrini, O., Mathy, N., Condon, C., and Bénard, L. (2008) In vitro assays of 5’ to 3’ exoribonuclease activity. Methods in Enzymology (448) 167-183.
  54. Deikus, G., Condon, C. and Bechhofer, D.H. (2008) Role of Bacillus subtilis RNase J1 endonuclease and 5’-exonuclease activities in trp leader mRNA turnover. J. Biol. Chem. 283:17158-17167.
  55. Redko, Y., Bechhofer,  D.H. and Condon, C. (2008) Mini-III, an ususual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis. Mol. Microbiol. 68:1096-1106.
  56. Condon, C. Maturation and degradation of RNA in bacteria. (2007) Curr. Opin. Microbiol. 10: 271-278.
  57. Mathy*, N., Bénard*, L., Pellegrini, O., Daou, R., Wen, T. and Condon. C. 5’-to-3’ exoribonuclease activity in Bacteria: Role of RNase J1 in rRNA maturation and 5’ stability of mRNA. (2007) Cell 129:681-692. *Co-first authors.
  58. Redko, Y., Li de la Sierra-Gallay, I., Condon, C. (2007) When all’s Zed and done : the structure and function of RNase Z in prokaryotes. Nature Rev. Micro. 5 : 278-286.
  59. Britton, R.A., Wen, T., Schaefer, L., Pellegrini, O., Uicker, W.C., Mathy, N., Tobin, C., Daou, R., Szyk, J. and Condon, C. (2007) Maturation of the 5’-end of B. subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1. Mol. Microbiol. 63 :127-137.
  60. Condon, C. (2006) Shutdown decay of mRNA. Mol. Microbiol. 61 :573-583.
  61. Li de la Sierra-Gallay, I., Mathy, N. Pellegrini, O. and Condon, C. (2006) Structure of the ubiquitous 3’ processing enzyme RNase Z bound to tRNA. Nature Mol. Str. Biol. 13:376-377.
  62. Wegscheid, B., Condon, C. and Hartmann, R. (2006) Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences. EMBO Rep.7:411-417.
  63. Todeschini, A.-L., Condon, C. and Bénard, L. (2006) Sodium-induced GCN4 expression controls the accumlation of the 5' to 3' RNA degradation inhibitor, 3'-phospho-adenosine-5'-phosphate. J. Biol. Chem. 281:3276-82.
  64. Allemand, F., Mathy, N., Brechemier-Baey, D. and Condon, C. (2005) The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member. Nucleic Acids Res. (33) 4368-4376.
  65. Wen, T., Oussenko, I.A., Pellegrini, O., Bechhofer, D.H., Condon, C. (2005) Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis. Nucleic Acids Res. (33) 3636-3643.
  66. Drider, D. and Condon, C. (2005). The continuing story of endoribonuclease III. J. Mol. Micro. Biotech. (8) 195-200.
  67. Pellegrini, O., Mathy, N., Gogos, A., Shapiro, L. and Condon, C. (2005) The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Mol. Microbiol. 56(5):1139-48.
  68. Li de la Sierra-Gallay, I., Pellegrini, O. and Condon, C. (2005) Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z. Nature. (433) 657-661.
  69. Baker, K. E and Condon, C. (2004) Under the Tucson sun: A meeting in the desert on mRNA decay. RNA (10) 1680 – 1691.
  70. Even, S., Brito, R., Condon, C. and Putzer H. (2003) Aminoacyl-tRNA synthetase gene regulation in bacteria. Recent Res. Devel. Bacteriol. (1) 201-217.
  71. Pellegrini, O., Nezzar, J, Marchfelder, A., Putzer, H. and Condon, C. (2003) Endonucleolytic processing of CCA-less tRNA precursors in Bacillus subtilis. EMBO J. (22) 4534-4543.
  72. Condon, C. RNA processing and degradation in Bacillus subtilis. (2003)Microbiol. Molec. Biol. Rev.(67) 157-174.
  73. Squires, C. L., Condon, C. and Seoh, H-K. (2003) In vitro antitermination assay of ribosomal RNA transcription.Methods Enz.(371) 472-487.
  74. Condon, C. and Putzer, H. (2002) The phylogenetic distribution of bacterial ribonucleases. Nucleic Acids Res.(30) 5339-5346.
  75. Putzer, H., Condon, C., Brechemier-Baey, D., Brito, R. and Grunberg-Manago, M.(2002) Transfer RNA-mediated antitermination in vitro. Nucleic Acids Res. (30) 3026-3033.
  76. Condon, C.,Rourera, J., Brechemier-Baey, D., and Putzer, H. (2002) Ribonuclease M5 has few, if any, messenger RNA substrates in Bacillus subtilis.J. Bact.(184) 2845-2849.
  77. Torres, M., Condon, C., Balada, J-M., Squires, C., and Squires, C. L. (2001) Ribosomal protein S4 is a transcription factor with properties remarkably similar to NusA, a protein involved in both non-ribosomal and ribosomal RNA transcription antitermination. EMBO J. (20) 3811-3820.
  78. Condon, C. Brechemier-Baey, D., Beltchev, B., Grunberg-Manago, M. and Putzer, H. (2001) Identification of the gene encoding the 5S ribosomal RNA maturase in Bacillus subtilis: mature 5S rRNA is dispensable for ribosome function. RNA (7) 242-253.
  79. Asai, T., Condon, C., Voulgaris, J., Zaporojets, D., Shen, B., Al-Omar, M., Squires, C., Squires, C. L. (1999) Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons. J. Bacteriol. (181) 3803-3809.
  80. Luo, D., Condon, C., Grunberg-Manago, M., and H. Putzer. (1998) In vitro and in vivo secondary structure probing of the thrS leader inBacillus subtilis. Nucl. Acids Res. (26) 5379-5387.
  81. Condon, C., Luo, D., Putzer, H., and M. Grunberg-Manago. (1997) Processing of the Bacillus subtilis thrS leader mRNA is RNAse E-dependent in Escherichia coli. J. Mol. Biol. (268) 235-242.
  82. Condon, C., Grunberg-Manago, M., and H. Putzer. (1996) Aminoacyl-tRNA gene regulation in Bacillus subtilis. Biochimie. (78) 381-389.
  83. Condon, C., Putzer, H., and M. Grunberg-Manago. (1996) Processing of the leader mRNA plays a major role in the induction of thrS expression following threonine starvation in B. subtilis. Proc. Natl. Acad. Sci. USA. (93) 6992-6997.
  84. Condon, C., Squires, C. and Squires, C. L. (1995) The control of ribosomal RNA transcription in Escherichia coli. Microbiol. Reviews. (59) 623-645.
  85. Condon, C., Liveris, D., Squires, C., Schwartz, I. and Squires, C. L. (1995) Ribosomal RNA operon multiplicity in Escherichia coli and the physiological implications of rrn inactivation. J. Bacteriol. (179) 4152-4156.
  86. Heinrich, T., Condon, C., Pfeiffer, T. and Hartmann, R. (1995) Point mutations in the leader boxA of a plasmid-encoded E. coli rrnB operon cause defective antitermination in vivo. J. Bacteriol. (177) 3793-3800.
  87. Putzer, H., Laalami, S., Brakhage, A. A., Condon, C. and M. Grunberg-Manago. (1995) Aminoacyl tRNA synthetase gene regulation in B. subtilis: induction repression and growth rate regulation. Molec. Microbiol. (16) 709-718.
  88. Condon, C. (1994) The control of ribosomal RNA transcription in Escherichia coli. Ph.D. Thesis, Columbia University, New York, NY 10027.
  89. Condon, C., French, S., Squires, C. and Squires, C. L. (1993) Depletion of functional ribosomal RNA operons in Escherichia coli causes increased expression of the remaining intact copies. EMBO J. (12) 4305-4315.
  90. Squires, C. L., Greenblatt, J., Li, J., Condon, C. and Squires, C. L. (1993) Ribosomal RNA antitermination in vitro: requirement for Nus factors and one or more unidentified cellular components. Proc. Natl. Acad. Sci. USA (90) 970-974.
  91. Condon, C., Phillips, J., Fu, Z-Y., Squires, C. and Squires, C. L. (1992) Comparison of the expression of the seven ribosomal RNA operons of Escherichia coli. EMBO J. (11) 4175-4185.
  92. Condon, C., Fitzgerald, R. J. and O' Gara, F. (1991) Conjugation and heterologous gene expression in Gluconobacter oxydans ssp. suboxydans. FEMS Micro. Lett. (80) 173-178.